EFFECT OF LASER INTENSITY PROFILE ON THE MICROSTRUCTURE AND TEXTURE OF INCONEL 718 SUPERALLOY FABRICATED BY DIRECT ENERGY DEPOSITION

Effect of laser intensity profile on the microstructure and texture of Inconel 718 superalloy fabricated by direct energy deposition

Epitaxial growth of dendrites often results in a strong texture, which is a common phenomenon in a laser additive manufacturing process.In this study, pulsed lasers with flat-top and Gaussian intensity profiles were used to modulate the molten pool morphology and the solidification texture with a unidirectional scanning strategy.The melt pool is pl

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RNA biology of disease-associated microsatellite repeat expansions

Abstract Microsatellites, or simple tandem repeat sequences, occur naturally in the human genome and have important roles in genome evolution and function.However, the expansion of microsatellites is associated with over two dozen neurological diseases.A common denominator among the majority of these Kettle disorders is the expression of expanded t

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Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and its relationship with neuroticism, cognition and risk of depression

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are encoded by four genes (HCN1-4) and, through activation by Square End Table cyclic AMP (cAMP), represent a point of convergence for several psychosis risk genes.On the basis of positive preliminary data, we sought to test whether genetic variation in HCN1-4 conferred risk of depr

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